Chirwere cheitsvo chisingaperi (CKD) varwere vanowanzova ne hyperphosphatemia, uye kwenguva refu hyperphosphatemia inogona kutungamirira kumatambudziko akakomba akadai sechipiri hyperparathyroidism, renal osteodystrophy, uye chirwere chemwoyo. Kudzora mazinga ephosphorous yeropa chikamu chakakosha chekutonga kwevarwere veCKD, uye ma phosphate binders ndiwo mishonga yekona yekurapa hyperphosphatemia. Mumakore achangopfuura,lanthanum carbonate, semhando itsva ye-non-calcium uye isiri-aruminiyamu phosphate binder, zvishoma nezvishoma yakapinda munharaunda yevanhu yekuona uye yakatanga "makwikwi" nemabhaidha echinyakare phosphate.
Izvo "zvakakodzera" uye "kukanganisa" kwechinyakare phosphate binders
Traditional phosphate binders kunyanya zvinosanganisira calcium-containing phosphate binders (senge calcium carbonate uye calcium acetate) uye aruminiyamu-ine phosphate binders (yakadai sealuminium hydroxide). Ivo vanobatana ne phosphates muchikafu kuti vaumbe zvisinganyunguriki makomisheni, nokudaro vachideredza kunyura kwe phosphorus muura.
Calcium-ine phosphate binders: Mutengo wakaderera uye phosphorus-inoderedza mhedzisiro, asi kushandiswa kwenguva refu kunogona kukonzera hypercalcemia uye kuwedzera njodzi yevascular calcification.
Aluminium-ine phosphorous binders: Yakasimba phosphorus yekudzikisa mhedzisiro, asi aruminiyamu kuunganidzwa kune muchetura zvakanyanya uye inogona kukonzera aluminium-inoenderana nemapfupa chirwere uye encephalopathy, uye parizvino iri kushoma kushandiswa.
Lanthanum carbonate: Kusimuka mutsva, ine zvakanakira zvakanakira
Lanthanum carbonate icarbonate yerare Earth metal element lanthanum, ine yakasarudzika phosphorus kusunga michina. Inoburitsa lanthanum ions munzvimbo ine acidic yemudumbu uye inoumba yakanyanya insoluble lanthanum phosphate ine phosphate, nokudaro ichidzivirira kubatwa kwephosphorus.
Sumo pfupi ye lanthanum carbonate
| Product name | Lanthanum carbonate |
| Formula | La2(CO3)3.xH2O |
| CAS Nha. | 6487-39-4 |
| Molecular Weight | 457.85 (anhy) |
| Density | 2.6 g/cm3 |
| Melting point | N/A |
| Chitarisiko | White crystal powder |
| Solubility | Soluble mumvura, zvine mwero soluble mune yakasimba mineral acids |
| Kugadzikana | Zviri nyore hygroscopic |
Kana ichienzaniswa neyechinyakare phosphorus binders, lanthanum carbonate ine zvinotevera zvakanakira:
Hapana calcium uye aluminium, kuchengetedzwa kwepamusoro: Inodzivirira njodzi ye hypercalcemia uye aluminium chepfu, kunyanya kune varwere vane kurapwa kwenguva refu uye njodzi yevascular calcification.
Yakasimba phosphorus kusunga kugona, yakakosha phosphorus yekuderedza mhedzisiro: Lanthanum carbonate inogona kunyatsosunga phosphorus muhupamhi pH renji, uye kugona kwayo kusunga kwakasimba kupfuura echinyakare phosphorus binders.
Kuita kushoma kwegastrointestinal kwakashata, kutevedzera murwere kwakanaka: Lanthanum carbonate inonaka, iri nyore kutora, haina kushatirwa kwemudumbu, uye varwere vanowanzoomerera pakurapwa kwenguva refu.
Clinical research evidence: Lanthanum carbonate inoita zvakanaka
Zvidzidzo zvakawanda zvekiriniki zvakasimbisa kushanda uye kuchengetedzwa kwelanthanum carbonate muvarwere veCKD. Zvidzidzo zvakaratidza kuti lanthanum carbonate haisi yakaderera kune kana kunyange yepamusoro kune echinyakare phosphate binders mukuderedza mazinga ephosphorous yeropa, uye inogona kunyatso kudzora mazinga ePTH nekuvandudza zviratidzo zvemasabolism emapfupa. Mukuwedzera, kuchengetedzwa kwekurapa kwenguva refu ne lanthanum carbonate kwakanaka, uye hapana pachena kuunganidza lanthanum uye maitiro ane chepfu akawanikwa.
Kurapa kwega: Sarudza chirongwa chakanakisa chemurwere
Kunyange zvazvo lanthanum carbonate ine zvakawanda zvakanaka, hazvirevi kuti inogona kutsiva zvachose phosphate binders. Mushonga wega wega une zviratidzo uye contraindications, uye chirongwa chekurapa chinofanirwa kuve chakasarudzika maererano nemamiriro chaiwo omurwere.
Lanthanum carbonate inonyanya kukodzera kune vanotevera varwere:
Varwere vane hypercalcemia kana njodzi ye hypercalcemia
Varwere vane vascular calcification kana njodzi yevascular calcification
Varwere vasina kushivirira zvakanaka kana kusashanda zvakanaka kwechinyakare phosphate binders
Traditional phosphate binders inogona kushandiswa kune vanotevera varwere:
Varwere vane mamiriro ehupfumi mashoma
Varwere vane allergic kune kana kusashivirira kwelanthanum carbonate
Kutarisa kune ramangwana: Lanthanum carbonate ine ramangwana rakajeka
Nekudzika kwekutsvakurudza kwekliniki uye kuunganidza ruzivo rwechipatara, chimiro che lanthanum carbonate mukurapa hyperphosphatemia muvarwere veCKD icharamba ichivandudza. Mune ramangwana, lanthanum carbonate inotarisirwa kuve yekutanga-line phosphate binder, ichiunza nhau dzakanaka kune vakawanda varwere veCKD.
Nguva yekutumira: Mar-25-2025