Masayendisiti akagadzira chikuva chekuunganidza nanosized zvinhu zvinoumba, kana "nano-zvinhu," zvemhando dzakasiyana kwazvo - inorganic kana organic - mune inodiwa 3-D zvimiro.Kunyangwe self-assembly (SA) yakabudirira kushandiswa kuronga nanomaterials emarudzi akati wandei, maitiro anga akanyanya sisitimu-chaiyo, achigadzira akasiyana zvimiro zvinoenderana nemukati mezvinhu zvemidziyo.Sezvakataurwa mubepa rakabudiswa nhasi muNature Materials, yavo itsva DNA-programmable nanofabrication platform inogona kushandiswa kuronga zvakasiyana-siyana zve 3-D zvinhu nenzira dzakatemerwa pa nanoscale (mabhiriyoni emamita), apo yakasiyana-siyana yemaziso, kemikari. , uye zvimwe zvinhu zvinobuda.
"Chimwe chezvikonzero chikuru nei SA isiri nzira yesarudzo yekushandisa inoshanda ndeyekuti iyo yakafanana nzira yeSA haigone kushandiswa muhuwandu hwakawanda hwezvinhu kugadzira yakafanana 3-D yakarongedzerwa arrays kubva akasiyana nanocomponents," akatsanangura anowirirana munyori Oleg Gang. , mutungamiri weSoft and Bio Nanomaterials Group paCentre for Functional Nanomaterials (CFN) - Dhipatimendi reMagetsi reUS (DOE) Hofisi yeSainzi User Facility paBrookhaven National Laboratory - uye purofesa we Chemical Engineering uye yeApplied Physics uye Materials Science. kuColumbia Engineering."Pano, takabvisa maitiro eSA kubva pazvinhu zvenyama nekugadzira akaomesesa polyhedral DNA mafuremu anogona kuvharidzira zvakasiyana-siyana inorganic kana organic nano-zvinhu, zvinosanganisira simbi, semiconductors, uye kunyange mapuroteni nema enzymes."
Masayendisiti akagadzira mafuremu eDNA ekugadzira muchimiro checube, octahedron, uye tetrahedron.Mukati memafuremu mune DNA "maoko" ayo chete nano-zvinhu zvine mubatanidzwa weDNA kutevedzana anogona kusunga.Aya ma voxels ezvinyorwa - kubatanidzwa kweDNA furemu uye nano-chinhu - ndiwo matombo ekuvaka anogona kugadzirwa macroscale 3-D zvimiro.Mafuremu anobatana kune mumwe nemumwe zvisinei nekuti rudzii rwe nano-chinhu chiri mukati (kana kwete) zvinoenderana neanopindirana akatevedzana iwo encoded nawo pamavertices avo.Zvichienderana nechimiro chavo, mafuremu ane nhamba yakasiyana yemavertices uye nokudaro anoumba zvimiro zvakasiyana zvachose.Chero nano-zvinhu zvakabatwa mukati memafuremu zvinotora iyo chaiyo furemu chimiro.
Kuti varatidze maitiro avo ekuunganidza, masayendisiti akasarudza simbi (goridhe) uye semiconducting (cadmium selenide) nanoparticles uye bhakitiriya reprotein (streptavidin) sezvinhu zvisingaverengeki uye organic nano-zvinhu kuti zviiswe mukati meDNA mafuremu.Chekutanga, vakasimbisa kuvimbika kwemafuremu eDNA uye kuumbwa kwemavoxels emhando kuburikidza nekufungidzira nema electron microscopes paCFN Electron Microscopy Facility uye Van Andel Institute, iyo ine suite yezviridzwa zvinoshanda pakupisa kwecryogenic kune biological samples.Vakazoongorora zvimiro zve3-D lattice paCoherent Hard X-ray Scattering and Complex Materials Scattering beamlines eNational Synchrotron Light Source II (NSLS-II) - imwe DOE Hofisi yeScience User Facility kuBrookhaven Lab.Columbia Engineering Bykhovsky Purofesa weChemical Engineering Sanat Kumar neboka rake vakaita computational modelling zvichiratidza kuti zvimiro zvakacherechedzwa zvelatisi (zvichibva pa x-ray yekuparadzira mapatani) ndiwo akanyanya kudzikama thermodynamically ayo anogona kuumbwa nemavoxels.
"Izvi ma voxels anotitendera kuti titange kushandisa pfungwa dzakatorwa kubva kumaatomu (uye mamorekuru) uye makristasi avanoumba, uye kuendesa ruzivo urwu rwakakura uye dhatabhesi kune masisitimu ekufarira pananoscale," akatsanangura Kumar.
Vadzidzi veGang paColumbia vakabva varatidza kuti chikuva chegungano chingashandiswa sei kufambisa kurongeka kwemhando mbiri dzakasiyana dzezvinhu zvine makemikari nemaziso.Mune imwe nyaya, vakaunganidza ma enzymes maviri, vachigadzira 3-D arrays ane yakakwira kurongedza.Kunyangwe ma enzymes akaramba asina kuchinjika mumakemikari, airatidza kuwedzera kwakapetwa kane mukuita enzymatic.Aya ma "nanoreactors" anogona kushandiswa kushandura maitikiro azvinoita uye kugonesa kugadzirwa kwezvinhu zvine makemikari anoshanda.Nekuratidzwa kwezvinhu zvemaziso, vakasanganisa mavara maviri akasiyana emhando dzemadotsi - madiki nanocrystals ari kushandiswa kugadzira terevhizheni nekuzara kwemavara uye kupenya.Mifananidzo yakatorwa nemaikorosikopu yefluorescence yakaratidza kuti latisi yakaumbwa yaichengetedza kuchena kweruvara pazasi pemuganhu we diffraction (wavelength) yechiedza;ichi chivakwa chinogona kubvumidza kwakakosha kugadzirisa kuvandudzwa mune dzakasiyana siyana kuratidza uye optical kutaurirana matekinoroji.
"Tinofanirwa kufunga zvakare kuti zvinhu zvingagadzirwa sei uye kuti zvinoshanda sei," akadaro Gang.“Kugadziridzazve zvinhu kungasava kuri madikanwa;kungorongedza zvinhu zviripo nenzira itsva zvinogona kuwedzera zvivakwa zvavo.Zvichigona, chikuva chedu chinogona kunge chiri tekinoroji inogonesa 'kupfuura 3-D kudhinda kugadzira' kudzora zvinhu pazvikero zvidiki zvakanyanya uye nehukuru hwezvinhu zvakasiyana-siyana uye zvakagadzirirwa zvinyorwa.Kushandisa nzira imwe chete yekugadzira 3-D lattices kubva kune inodiwa nano-zvinhu zvemakirasi akasiyana ezvinyorwa, kubatanidza izvo zvinganzi hazvienderane, zvinogona kushandura nanomanufacturing.
Zvishandiso zvinopihwa neDOE/Brookhaven National Laboratory.Cherechedzo: Zviri mukati zvinogona kugadziridzwa sechimiro uye kureba.
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Nguva yekutumira: Jul-04-2022